Article
FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies.
Allergy - 1 Jan 2012
Standl M, Sausenthaler S, Lattka E, Koletzko S, Bauer C-P, Wichmann H-E, von Berg A, Berdel D, Krämer U, Schaaf B, Lehmann I, Herbarth O, Klopp N, Koletzko B, Heinrich J
Abstract excerpt
BACKGROUND: The protective effect of breastfeeding (BF) on the development of asthma has been widely recognized, even if not all results have been consistent. Gene variants of the FADS gene cluster have a major impact on fatty acid composition in blood and in breast milk. Therefore, we evaluated the influence of the FADS1 FADS2 gene cluster polymorphisms on the association between BF and asthma. METHODS: The...
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