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Article

The onion model, a simple neutral model for the evolution of diversity in bacterial biofilms.

Journal of evolutionary biology - 1 Nov 2011

Eastman J M, Harmon L J, LA H-J, Joyce P, Forney L J

Abstract excerpt

Bacterial biofilms are particularly resistant to a wide variety of antimicrobial compounds. Their persistence in the face of antibiotic therapies causes significant problems in the treatment of infectious diseases. Seldom have evolutionary processes like genetic drift and mutation been invoked to explain how resistance to antibiotics emerges in biofilms, and we lack a simple and tractable model for the genetic...

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PMID: 21929684
DOI: 10.1111/j.1420-9101.2011.02377.x

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