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Article

Streptococcus pneumoniae serotype 9A isolates contain diverse mutations to wcjE that result in variable expression of serotype 9V-specific epitope.

The Journal of infectious diseases - 15 Nov 2011

Calix Juan J, Oliver Melissa B, Sherwood Logan K, Beall Bernard W, Hollingshead Susan K, Nahm Moon H

Abstract excerpt

BACKGROUND: Streptococcus pneumoniae is a significant pathogen capable of expressing protective and antigenically diverse capsules. To better understand the molecular basis of capsular antigenic diversity, we investigated the hypothetical serological role of wcjE, which encodes a capsule O-acetyltransferase, in the vaccine-targeted serotype 9V and related serotype 9A. METHODS: We inactivated wcjE by recombination...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21908730
DOI: 10.1093/infdis/jir593
PMCID: PMC3222105

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