The Malaria Parasite Progressively Dismantles the Host Erythrocyte Cytoskeleton for Efficient Egress

Abstract excerpt

Plasmodium falciparum is an obligate intracellular pathogen responsible for worldwide morbidity and mortality. This parasite establishes a parasitophorous vacuole within infected red blood cells wherein it differentiates into multiple daughter cells that must rupture their host cells to continue another infectious cycle. Using atomic force microscopy, we establish that progressive macrostructural changes occur to...

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