The ERM protein, Ezrin, regulates neutrophil transmigration by modulating the apical localization of MRP2 in response to the SipA effector protein during Salmonella Typhimurium infection

Abstract excerpt

In human disease induced by Salmonella enterica serovar Typhimurium (S. Typhimurium), transepithelial migration of neutrophils rapidly follows attachment of the bacteria to the epithelial apical membrane. We have previously shown that during S. Typhimurium infection the multidrug resistance-associated protein 2 (MRP2) is highly expressed at the apical surface of the intestinal epithelia, and that it functions as...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Caveolin-1 and cellular processes
• Share to Cell Adhesion Molecules Research
• Share to Glycosylation and Glycoproteins Research