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Article

Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.

Journal of cellular physiology - 1 Jun 2012

Rankin Andrew M, Sarkar Sibaji, Faller Douglas V

Abstract excerpt

DNA oligonucleotides with sequence homology to human telomeric DNA (T-oligo) induce cell cycle arrest, followed by apoptosis, senescence, or autophagy in a human cancer cell type-specific manner. T-oligo has potential as a new therapeutic strategy in oncology because of its ability to target certain types of tumor cells while sparing normal ones. In the present study, we demonstrate the T-oligo-induced S-phase...

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Identifiers

PMID: 21898405
DOI: 10.1002/jcp.22997
PMCID: PMC3251650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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