Article
Use of direct sequencing for detection of mutations in the BCR-ABL kinase domain in Slovak patients with chronic myeloid leukemia.
Neoplasma - 1 Jan 2011
Strhakova L, Bujalkova M Gerykov, Hojsikova I, Lukackova R, Behulova R, Mistrik M, Repiska V
Abstract excerpt
The presence of BCR-ABL oncogene mutations in patients with chronic myeloid leukemia (CML) may be responsible for the failure of tyrosine kinase inhibitor (TKI) treatment. The aim of the study was to evaluate the frequency of BCR-ABL gene mutations in patients with CML treated with tyrosine kinas...
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