Article
Sequence analysis of the 2009 pandemic influenza A H1N1 virus haemagglutinin gene from 2009-2010 Brazilian clinical samples.
Memorias do Instituto Oswaldo Cruz - 1 Aug 2011
Ferreira João Leandro de Paula, Borborema Samanta Etel Treiger, Brígido Luis Fernando de Macedo, Oliveira Maria Isabel de, Paiva Terezinha Maria de, Santos Cecília Luiza Simões dos
Abstract excerpt
In this paper, we analysed the haemagglutinin (HA) gene identified by polymerase chain reaction from 90 influenza A H1N1 virus strains that circulated in Brazil from April 2009-June 2010. A World Health Organization sequencing protocol allowed us to identify amino acid mutations in the HA protein at positions S220T (71%), D239G/N/S (20%), Y247H (4.5%), E252K (3.3%), M274V (2.2%), Q310H (26.7%) and E391K (12%). A...
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