Article
β-Thalassemia mutations in subjects with borderline HbA₂ values: a pilot study in North India.
Clinical chemistry and laboratory medicine - 6 Sept 2011
Rangan Aruna, Sharma Prashant, Dadu Tina, Saxena Renu, Verma Ishwar C, Bhargava Manorama
Abstract excerpt
BACKGROUND: Interpreting hemoglobin high performance liquid chromatograms with borderline HbA₂ values is often problematic, especially in antenatal cases if the partner is a known thalassemia trait. METHODS: We tested for underlying β-thalassemia mutations in 25 subjects with borderline HbA₂ values (between 3.0%-4.0%). Amplification refractory mutation system (ARMS-PCR) was used to detect the five common Indian...
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