Urinary bladder cancer risk in relation to a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor-binding protein-3 (IGFBP3) gene.

doi:10.1007/s00204-011-0747-5

Article

Urinary bladder cancer risk in relation to a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor-binding protein-3 (IGFBP3) gene.

Archives of toxicology - 1 Feb 2012

Selinski Silvia, Lehmann Marie-Louise, Blaszkewicz Meinolf, Ovsiannikov Daniel, Moormann Oliver, Guballa Christoph, Kress Alexander, Truss Michael C, Gerullis Holger, Otto Thomas, Barski Dimitri, Niegisch Günter, Albers Peter, Frees Sebastian, Brenner Walburgis, Thüroff Joachim W, Angeli-Greaves Miriam, Seidel Thilo, Roth Gerhard, Volkert Frank, Ebbinghaus Rainer, Prager Hans-Martin, Lukas Cordula, Bolt Hermann M, Falkenstein Michael, Zimmermann Anna, Klein Torsten, Reckwitz Thomas, Roemer Hermann C, Hartel Mark, Weistenhöfer Wobbeke, Schöps Wolfgang, Rizvi S Adibul Hassan, Aslam Muhammad, Bánfi Gergely, Romics Imre, Ickstadt Katja, Hengstler Jan G, Golka Klaus

Abstract excerpt

Currently, twelve validated genetic variants have been identified that are associated with urinary bladder cancer (UBC) risk. However, those validated variants explain only 5-10% of the overall inherited risk. In addition, there are more than 100 published polymorphisms still awaiting validation or disproval. A particularly promising of the latter unconfirmed polymorphisms is rs2854744 that recently has been...

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Urinary bladder cancer risk in relation to a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor-binding protein-3 (IGFBP3) gene.

Abstract excerpt

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