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Article

CCG polymorphisms in the huntingtin gene have no effect on the pathogenesis of patients with Huntington's disease in mainland Chinese families.

Journal of the neurological sciences - 15 Jan 2012

Zhang Bao-rong, Tian Jun, Yan Ya-ping, Yin Xin-zhen, Zhao Guo-hua, Wu Zhi-ying, Gu Wei-hong, Xia Kun, Tang Bei-sha

Abstract excerpt

Huntington's disease (HD) is caused by the abnormal expansion of CAG repeats in the huntingtin gene (HTT). The adjacent proline-rich region, which also has a CCG polymorphism among people of different races, may also affect the pathogenesis of HD. To study the effect of this polymorphism on patients with HD in mainland China, 53 HD mutant alleles were examined. The results showed that 54.72% of the HD mutant...

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Source

Identifiers

PMID: 21875723
DOI: 10.1016/j.jns.2011.08.015

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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