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Article

Proteomic and transcriptomic analysis of linezolid resistance in Streptococcus pneumoniae.

Journal of proteome research - 7 Oct 2011

Feng Jie, Billal Dewan S, Lupien Andréanne, Racine Gina, Winstall Eric, Légaré Danielle, Leprohon Philippe, Ouellette Marc

Abstract excerpt

Linezolid is an oxazolidinone antibiotic that inhibits the initiation of translation. Although resistance to linezolid is an uncommon event, it has been reported in clinical isolates. The genome sequence of Streptococcus pneumoniae linezolid-resistant mutants recently revealed mutations associated with resistance. A proteomic and transcriptomic screen now reveals a possible increase in the metabolism and...

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PMID: 21875071
DOI: 10.1021/pr200221s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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