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Article

Acquired activated protein C resistance, thrombophilia and adverse pregnancy outcomes: a study performed in an Irish cohort of pregnant women.

Journal of pregnancy - 1 Jan 2011

Sedano-Balbás Sara, Lyons Mark, Cleary Brendan, Murray Margaret, Gaffney Geraldine, Maher Majella

Abstract excerpt

The combination of thrombophilia and pregnancy increases the risk of thrombosis and the potential for adverse outcomes during pregnancy. The most significant common inherited risk factor for thrombophilia is activated protein C resistance (APCR), a poor anticoagulant response of APC in haemostasis, which is mainly caused by an inherited single-nucleotide polymorphism (SNP), factor V G1691A (FV Leiden) (FVL),...

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Source

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Identifiers

PMID: 21869933
DOI: 10.1155/2011/232840
PMCID: PMC3157763

Genes

APC
MTHFR

Variants

Provenance

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