Article
Self-organizing map of gene regulatory networks for cell phenotypes during reprogramming.
Computational biology and chemistry - 10 Aug 2011
Zhang Leping, Zheng Yufang, Li Dongfang, Zhong Yang
Abstract excerpt
The induced pluripotent cells (iPSCs) are derived from somatic cells by reprogramming their genetic profiles. Such a process requires coordinated dynamic expression of hundreds of genes and proteins. As both deterministic and stochastic elements control the reprogramming process, it is not easy to have a way to reflect the status of gene regulatory network in those reprogramming cells. In this study, we applied...
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