Article
Uncovering genomic causes of co-morbidity in epilepsy: gene-driven phenotypic characterization of rare microdeletions.
PloS one - 1 Jan 2011
Kasperavičiūtė Dalia, Catarino Claudia B, Chinthapalli Krishna, Clayton Lisa M S, Thom Maria, Martinian Lillian, Cohen Hannah, Adalat Shazia, Bockenhauer Detlef, Pope Simon A, Lench Nicholas, Koltzenburg Martin, Duncan John S, Hammond Peter, Hennekam Raoul C M, Land John M, Sisodiya Sanjay M
Abstract excerpt
BACKGROUND: Patients with epilepsy often suffer from other important conditions. The existence of such co-morbidities is frequently not recognized and their relationship with epilepsy usually remains unexplained. METHODOLOGY/PRINCIPAL FINDINGS: We describe three patients with common, sporadic, non-syndromic epilepsies in whom large genomic microdeletions were found during a study of genetic susceptibility to...
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