MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas

Abstract excerpt

The BMI1 gene is overexpressed in ≈ 90% of human neuroblastomas. However, little is known about the regulation of BMI1 expression. Using microarray and immunohistochemical analysis, we show that BMI1 expression correlated with MYCN levels in MYCN-amplified human neuroblastomas, and with MYC levels in the MYCN-nonamplified group. We further demonstrated that BMI1 is a direct target gene of MYCN/MYC in 3...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Microtubule and mitosis dynamics
• Share to Neuroblastoma Research and Treatments
• Share to Ubiquitin and proteasome pathways