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Article

Molecular oncology of lung cancer.

General thoracic and cardiovascular surgery - 1 Aug 2011

Toyooka Shinichi, Mitsudomi Tetsuya, Soh Junichi, Aokage Keiju, Yamane Masaomi, Oto Takahiro, Kiura Katsuyuki, Miyoshi Shinichiro

Abstract excerpt

Progress in genetic engineering has made it possible to elucidate the molecular biological abnormalities in lung cancer. Mutations in KRAS and P53 genes, loss of specific alleles, and DNA methylation of the tumor suppressor genes were the major abnormalities investigated between 1980 and the 2000s. In 2004, mutations in the epidermal growth factor receptor (EGFR) gene that cause oncogene addiction were discovered...

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Source

Identifiers

PMID: 21850578
DOI: 10.1007/s11748-010-0743-3

Genes

EGFR
ALK
EML4
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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