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Article

A Unique MicroRNA Signature Associated With Plaque Instability in Humans

5 Aug 2011

Abstract excerpt

BACKGROUND AND PURPOSE: Atherosclerotic plaque rupture is considered the most important mechanism that underlies the onset of stroke, myocardial infarction, and sudden death. Several evidences demonstrated the pivotal role of inflammatory processes in plaque destabilization. MicroRNAs (miRNAs) are small endogenous RNAs and represent a new important class of gene regulators. Nevertheless, no data exist about the...

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PMID: 21817153
DOI: 10.1161/strokeaha.110.597575

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