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Article

Genetic screening and double mutation in Japanese patients with hypertrophic cardiomyopathy.

Circulation journal : official journal of the Japanese Circulation Society - 1 Jan 2011

Kubo Toru, Kitaoka Hiroaki, Okawa Makoto, Baba Yuichi, Hirota Takayoshi, Hayato Kayo, Yamasaki Naohito, Matsumura Yoshihisa, Otsuka Haruna, Arimura Takuro, Kimura Akinori, Doi Yoshinori L

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal-dominant pattern of inheritance mainly caused by single heterozygous mutations in sarcomere genes. Although multiple gene mutations have recently been reported in Western countries, clinical implications of multiple mutations in Japanese subjects are not clear. METHODS AND RESULTS: A comprehensive genetic analysis of...

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Source

Identifiers

PMID: 21799269
DOI: 10.1253/circj.cj-10-1314

Genes

MYBPC3
MYH7
TNNI3
TNNT2
TPM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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