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Article

Biochemical Basis of Asthma Therapy

29 Jul 2011

Abstract excerpt

Current therapy for asthma is highly effective. β(2)-Adrenergic receptor (β(2)AR) agonists are the most effective bronchodilators and relax airway smooth muscle cells through increased cAMP concentrations and directly opening large conductance Ca(2+) channels. β(2)AR may also activate alternative signaling pathways that may have detrimental effects in asthma. Glucocorticoids are the most effective...

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PMID: 21799015
DOI: 10.1074/jbc.r110.206466

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