Low Birth Weight Is Associated with Reduced Nephron Number and Increased Blood Pressure in Adulthood in a Novel Spontaneous Intrauterine Growth-Restricted Model in Yucatan Miniature Swine

Abstract excerpt

BACKGROUND: Impaired fetal growth and rapid postnatal growth are associated with programming of hypertension and metabolic syndrome in adulthood. OBJECTIVES: This study evaluated this phenomenon in a novel spontaneous intrauterine growth-restricted (IUGR) model in Yucatan miniature pigs. METHODS: IUGR piglets (n = 6, 3 days old, 0.73 ± 0.11 kg) were paired with a normal weight (NW) same-sex littermate (n = 6,...

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