Article
Recombination rates in admixed individuals identified by ancestry-based inference.
Nature genetics - 20 Jul 2011
Wegmann Daniel, Kessner Darren E, Veeramah Krishna R, Mathias Rasika A, Nicolae Dan L, Yanek Lisa R, Sun Yan V, Torgerson Dara G, Rafaels Nicholas, Mosley Thomas, Becker Lewis C, Ruczinski Ingo, Beaty Terri H, Kardia Sharon L R, Meyers Deborah A, Barnes Kathleen C, Becker Diane M, Freimer Nelson B, Novembre John
Abstract excerpt
Studies of recombination and how it varies depend crucially on accurate recombination maps. We propose a new approach for constructing high-resolution maps of relative recombination rates based on the observation of ancestry switch points among admixed individuals. We show the utility of this approach using simulations and by applying it to SNP genotype data from a sample of 2,565 African Americans and 299...
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