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Article

Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.

Nature genetics - 24 Jul 2011

Gottipati Srikanth, Arbiza Leonardo, Siepel Adam, Clark Andrew G, Keinan Alon

Abstract excerpt

The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21775991
DOI: 10.1038/ng.877
PMCID: PMC3145052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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