Article
Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families.
BMC medical genetics - 21 Jul 2011
Vuorela Mikko, Pylkäs Katri, Winqvist Robert
Abstract excerpt
BACKGROUND: Currently known susceptibility genes such as BRCA1 and BRCA2 explain less than 25% of familial aggregation of breast cancer, which suggests the involvement of additional susceptibility genes. RNF8, UBC13 and MMS2 are involved in the DNA damage response pathway and play important roles in BRCA1-mediated DNA damage recognition. Based on the evidence that several players in the ubiquitin-mediated...
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