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Predictive performance for human skin sensitizing potential of the human cell line activation test (h-CLAT)

18 Jul 2011

Abstract excerpt

BACKGROUND: Recent changes in regulatory restrictions and social opposition to animal toxicology experiments have driven the need for reliable in vitro tests for predicting the skin sensitizing potentials of a wide variety of industrial chemicals. Previously, we developed the human cell line activation test (h-CLAT) as a cell-based assay to predict the skin sensitizing potential of chemicals, and showed the...

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PMID: 21767275
DOI: 10.1111/j.1600-0536.2011.01952.x

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