Article
Angiotensin-converting enzyme gene polymorphism and N-Acetyl-β-D-glucosaminidase excretion in endemic nephropathy.
Nephron. Clinical practice - 1 Jan 2011
Pećin Ivan, Cvorišćec Dubravka, Miletić-Medved Marica, Dika Zivka, Cvitković Ante, Vitale Ksenija, Leko Ninoslav, Novaković Dinko, Sertić Jadranka, Kos Jelena, Jelaković Bojan
Abstract excerpt
BACKGROUND: Tubular proteinuria and enzymuria are hallmarks of endemic nephropathy (EN). The role of I/D angiotensin convertase (ACE) gene polymorphism has not yet been elucidated in this peculiar chronic tubulointerstitial nephritis, and our aim was to investigate the role of this polymorphism in EN focusing on the urinary N-acetyl-β-D-glucosaminidase (NAG) excretion, a biomarker of proximal tubular damage....
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