Article
PTPN22 R620W genotype-phenotype correlation analysis and gene-environment interaction study in early rheumatoid arthritis: results from the ESPOIR cohort.
Rheumatology (Oxford, England) - 1 Oct 2011
Salliot Carine, Dawidowicz Karen, Lukas Cédric, Guedj Mickael, Paccard Caroline, Benessiano Joelle, Dougados Maxime, Nicaise Pascale, Meyer Olivier, Dieudé Phillippe
Abstract excerpt
OBJECTIVES: To investigate genotype-phenotype correlation and gene-environment interaction between PTPN22 R620W environmental factors such as tobacco/hormonal treatments in an inception cohort of RA patients. METHODS: An intra-cohort study including 532 Caucasian RA patients genotyped for the PTPN22 rs2476601 polymorphism was performed. Anti-CCP and RF status at baseline, presence of bone erosions at 1 year,...
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