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Article

Predictive Genes in Adjacent Normal Tissue Are Preferentially Altered by sCNV during Tumorigenesis in Liver Cancer and May Rate Limiting

5 Jul 2011

Abstract excerpt

BACKGROUND: In hepatocellular carcinoma (HCC) genes predictive of survival have been found in both adjacent normal (AN) and tumor (TU) tissues. The relationships between these two sets of predictive genes and the general process of tumorigenesis and disease progression remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: Here we have investigated HCC tumorigenesis by comparing gene expression, DNA copy number...

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Share to Genomic variations and chromosomal abnormalities
Share to Hepatocellular Carcinoma Treatment and Prognosis
Share to Microtubule and mitosis dynamics

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PMID: 21750698
DOI: 10.1371/journal.pone.0020090

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