Article
Sequence variation of the methylene tetrahydrofolate reductase gene (677C>T and 1298 A>C) and traditional risk factors in a South Indian population.
Genetic testing and molecular biomarkers - 1 Nov 2011
Dayakar Seetha, Goud Kalal Iravathy, Reddy Thavanati Parvathi Kumara, Rao Seshagiri P, Sesikeran Shyamala B, Sadhnani Muralidhar
Abstract excerpt
Methylene tetrahydrofolate reductase (MTHFR) plays a significant role in the metabolism of methionine. MTHFR deficiency is an autosomal recessive trait that could be a significant risk factor for a number of defects, for example, vascular events, due to lower dietary folate intake among South Indians. To find the incidence of 677 C>T and 1298 A>C in MTHFR gene single nucleotide polymorphisms (SNPs) among the...
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