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Article

Correlation of CYP2B6, CYP2C19, ABCC4 and SOD2 genotype with outcomes in allogeneic blood and marrow transplant patients.

Leukemia research - 1 Jan 2012

Black John L, Litzow Mark R, Hogan William J, O'Kane Dennis J, Walker Denise L, Lesnick Timothy G, Kremers Walter K, Avula Rajeswari, Ketterling Rhett P

Abstract excerpt

CYP2B6, CYP2C19, ABCC4, and SOD2 have been implicated in adverse drug reactions and survival after cyclophosphamide (CPA) treatment. 110 BMT patients who received high dose CPA treatment were genotyped for variants in these genes and the results were correlated with toxicity and relapse. CYP2B6 genotype significantly influenced overall toxicity suggesting active CYP2B6 alleles led to higher rates of overall...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21741706
DOI: 10.1016/j.leukres.2011.06.020

Genes

SOD2
ABCC4

Variants

rs4880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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