Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA interference and amyotrophic lateral sclerosis.

Current drug metabolism - 1 Sept 2011

Rizvanov Albert A, Gulluoglu Sukru, Yalvaç Mehmet E, Palotás András, Islamov Rustem R

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a debilitating neuro-degenerative disorder characterized by progressive loss of motor neurons. The etiology and molecular pathogenesis of cell death in most sub-types of the disease are largely unknown. The best documented cause of moto-neuron degeneration is the mutation in the superoxide dismutase-1 (SOD1) gene, which occurs in 10% of the familial forms of ALS. Discovery...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Cell Death
Share to SOD1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Therapy

Share to Mutation

Share to RNA Interference

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 21740381
DOI: 10.2174/138920011796504464

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA interference and amyotrophic lateral sclerosis.PMID 21740381Read ↗

Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS).Semantic proximity Read ↗

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model.Semantic proximity Read ↗

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis.Semantic proximity Read ↗

Recent advances in amyotrophic lateral sclerosis research.Semantic proximity Read ↗

Silencing strategies for therapy of SOD1-mediated ALS.Semantic proximity Read ↗

An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu,Zn superoxide dismutase.Semantic proximity Read ↗

Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression.Semantic proximity Read ↗

RNA Dysregulation in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cellsSemantic proximity Read ↗

Advancements in genetic research and RNA therapy strategies for amyotrophic lateral sclerosis (ALS): current progress and future prospectsSemantic proximity Read ↗

Current developments in gene therapy for amyotrophic lateral sclerosisSemantic proximity Read ↗

Recent Progress of Antisense Oligonucleotide Therapy for Superoxide Dismutase 1-mutated Amyotrophic Lateral Sclerosis: Focus on TofersenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.