Article
The bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression.
DNA and cell biology - 1 Nov 2011
Fredericks William J, McGarvey Terry, Wang Huiyi, Lal Priti, Puthiyaveettil Raghunath, Tomaszewski John, Sepulveda Jorge, Labelle Ed, Weiss Jayne S, Nickerson Michael L, Kruth Howard S, Brandt Wolfgang, Wessjohann Ludger A, Malkowicz S Bruce
Abstract excerpt
Convergent evidence implicates the TERE1 protein in human bladder tumor progression and lipid metabolism. Previously, reduced TERE1 expression was found in invasive urologic cancers and inhibited cell growth upon re-expression. A role in lipid metabolism was suggested by TERE1 binding to APOE, a cholesterol carrier, and to TBL2, a candidate protein in triglyceride disorders. Natural TERE1 mutations associate with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.