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RNA Binding by a Novel Helical Fold of B2 Protein from Wuhan Nodavirus Mediates the Suppression of RNA Interference and Promotes B2 Dimerization

7 Jul 2011

Abstract excerpt

Wuhan nodavirus (WhNV) is a newly identified member of the Nodaviridae family with a bipartite genome of positive-sense RNAs. A nonstructural protein encoded by subgenomic RNA3 of nodaviruses, B2, serves as a potent RNA silencing suppressor (RSS) by sequestering RNA duplexes. We have previously demonstrated that WhNV B2 blocks RNA silencing in cultured Drosophila cells. However, the molecular mechanism by which...

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PMID: 21734038
DOI: 10.1128/jvi.00785-11

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