Article
Sequestration and protection of double-stranded RNA by the betanodavirus b2 protein.
Journal of virology - 1 Jul 2006
Fenner Beau J, Goh Winnie, Kwang Jimmy
Abstract excerpt
Betanodavirus B2 belongs to a group of functionally related proteins from the sense-strand RNA virus family Nodaviridae that suppress cellular RNA interference. The B2 proteins of insect alphanodaviruses block RNA interference by binding to double-stranded RNA (dsRNA), thus preventing Dicer-mediated cleavage and the subsequent generation of short interfering RNAs. We show here that the fish betanodavirus B2...
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