Flavopiridol induces<i>BCL-2</i>expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia

Abstract excerpt

Flavopiridol is a cyclin-dependent kinase inhibitor that induces cell cycle arrest, apoptosis, and clinical responses in selected patients with acute myeloid leukemia (AML). A better understanding of the molecular pathways targeted by flavopiridol is needed to design optimal combinatorial therapy. Here, we report that in vivo administration of flavopiridol induced expression of the BCL-2 anti-apoptotic gene in...

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