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Article

Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy.

Cancer research - 15 Aug 2011

Yang Fei, Tang Ximing, Riquelme Erick, Behrens Carmen, Nilsson Monique B, Giri Uma, Varella-Garcia Marileila, Byers Lauren A, Lin Heather Y, Wang Jing, Raso Maria G, Girard Luc, Coombes Kevin, Lee J Jack, Herbst Roy S, Minna John D, Heymach John V, Wistuba Ignacio I

Abstract excerpt

VEGF receptor-2 (VEGFR-2 or kinase insert domain receptor; KDR) is a known endothelial target also expressed in NSCLC tumor cells. We investigated the association between alterations in the KDR gene and clinical outcome in patients with resected non-small-cell lung carcinoma (NSCLC; n = 248). KDR copy number gains (CNG), measured by quantitative PCR and fluorescence in situ hybridization, were detected in 32% of...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Chemotherapy, Adjuvant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Gene Dosage

Share to In Situ Hybridization, Fluorescence

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Share to Vascular Endothelial Growth Factor Receptor-2

Source

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Identifiers

PMID: 21724587
DOI: 10.1158/0008-5472.CAN-10-2614
PMCID: PMC3159530

Genes

KDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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