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Article

Variability in estrogen-metabolizing genes and their association with genomic instability in untreated breast cancer patients and healthy women.

Journal of biomedicine & biotechnology - 1 Jan 2011

dos Santos Raquel Alves, Teixeira Ana Cláudia, Mayorano Mônica Beatriz, Carrara Hélio Humberto Angotti, de Andrade Jurandyr, Takahashi Catarina Satie

Abstract excerpt

In the present study, we investigated the relationship between polymorphisms in the estrogen-metabolizing genes CYP17, CYP1B1, CYP1A1, and COMT and genomic instability in the peripheral blood lymphocytes of 62 BC patients and 62 controls considering that increased or prolonged exposure to estrogen can damage the DNA molecule and increase the genomic instability process in breast tissue. Our data demonstrated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

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Source

Open in PubMed Open full text

Identifiers

PMID: 21716904
DOI: 10.1155/2011/571784
PMCID: PMC3116633

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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