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Article

Resveratrol selectively induces DNA Damage, independent of Smad4 expression, in its efficacy against human head and neck squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2011

Tyagi Alpna, Gu Mallikarjuna, Takahata Takenori, Frederick Barbara, Agarwal Chapla, Siriwardana Sunitha, Agarwal Rajesh, Sclafani Robert A

Abstract excerpt

PURPOSE: Alterations in Smad4 signaling and its loss cause genomic instability and head and neck squamous cell carcinoma (HNSCC), suggesting that agents that target both Smad4-dependent and -independent pathways could control HNSCC. EXPERIMENTAL DESIGN: Resveratrol efficacy was evaluated against the HNSCC cells FaDu, Cal27, Det562, and Cal27-Smad4 for viability, DNA damage, cell-cycle progression, and apoptosis,...

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Identifiers

PMID: 21705453
DOI: 10.1158/1078-0432.CCR-11-1072
PMCID: PMC3156958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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