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Article

Thyroid hormone and DNA binding properties of a mutant c-erbA beta receptor associated with generalized thyroid hormone resistance.

Biochemical and biophysical research communications - 14 Sept 1990

Usala S J, Wondisford F E, Watson T L, Menke J B, Weintraub B D

Abstract excerpt

We have previously reported a family, Kindred A, with autosomal dominant generalized thyroid hormone resistance in which affected members were found to have a mutation in the carboxy-terminal domain of the c-erbA beta thyroid hormone receptor. In the current study, the thyroid hormone and DNA-binding properties of this mutant receptor were determined using c-erbA beta protein synthesized in vitro. Both the...

Topics

Cloning, Molecular
DNA
Gene Amplification
Growth Hormone
Humans
Kinetics
Mutation
Protein Binding
Protein Biosynthesis
Proto-Oncogene Proteins
Receptors, Thyroid Hormone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thyrotropin

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Identifiers

PMID: 2169728
DOI: 10.1016/0006-291x(90)91185-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2169728-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Thyroid hormone and DNA binding properties of a mutant c-erbA beta receptor associated with generalized thyroid hormone resistance.PMID 2169728Read ↗

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