Article
MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R.
PloS one - 1 Jan 2011
Lerman Galya, Avivi Camila, Mardoukh Corine, Barzilai Aviv, Tessone Ariel, Gradus Ben, Pavlotsky Felix, Barshack Iris, Polak-Charcon Sylvie, Orenstein Arie, Hornstein Eran, Sidi Yechezkel, Avni Dror
Abstract excerpt
BACKGROUND: Psoriasis is a complex disease at the cellular, genomic and genetic levels. The role of microRNAs in skin development was shown in a keratinocyte-specific Dicer knockout mouse model. Considering that two main characteristics of psoriasis are keratinocytes hyperproliferation and abnormal skin differentiation, we hypothesized that aberrant microRNA expression contributes to the psoriatic phenotype....
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