Article
Nonclassic TSH resistance: TSHR mutation carriers with discrepantly high thyroidal iodine uptake.
The Journal of clinical endocrinology and metabolism - 1 Aug 2011
Narumi Satoshi, Nagasaki Keisuke, Ishii Tomohiro, Muroya Koji, Asakura Yumi, Adachi Masanori, Hasegawa Tomonobu
Abstract excerpt
CONTEXT: Inactivating mutations in the TSH receptor gene (TSHR) cause TSH resistance. Most patients with TSH resistance have low to normal thyroidal radioiodine uptake (RAIU), which is consistent with the physiological knowledge that TSH stimulates iodine uptake. To date, only one TSHR mutation-carrying family with discrepantly high RAIU has been reported. OBJECTIVE: We aimed to test whether TSHR mutation...
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