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Article

Familial hypercholesterolemia: epidemiology, Neolithic origins and modern geographic distribution.

Critical reviews in clinical laboratory sciences - 1 Jan 2000

Liyanage Khemanganee E, Burnett John R, Hooper Amanda J, van Bockxmeer Frank M

Abstract excerpt

The elucidation of the molecular basis of familial hypercholesterolemia (FH) by Brown and Goldstein about three decades ago provided the most convincing evidence for a causative relationship between a high plasma level of low-density lipoprotein (LDL) cholesterol and the conditions of atherosclerosis and premature atherosclerotic cardiovascular disease. Today, with a prevalence of about one in 500 individuals, FH...

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Source

Identifiers

PMID: 21657943
DOI: 10.3109/10408363.2011.565585

Genes

LDLR
APOB
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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