Article
Analysis of H19 methylation in control and abnormal human embryos, sperm and oocytes.
European journal of human genetics : EJHG - 1 Nov 2011
Ibala-Romdhane Samira, Al-Khtib Mohamed, Khoueiry Rita, Blachère Thierry, Guérin Jean-François, Lefèvre Annick
Abstract excerpt
ART is suspected to generate increased imprinting errors in the lineage. Following an intra cytoplasmic sperm injection (ICSI) procedure, a certain number of embryos fail to develop normally and imprinting disorders may be associated to the developmental failure. To evaluate this hypothesis, we analysed the methylation profile of H19DMR, a paternally imprinting control region, in high-graded blastocysts, in...
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