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Mimivirus shows dramatic genome reduction after intraamoebal culture

6 Jun 2011

Abstract excerpt

Most phagocytic protist viruses have large particles and genomes as well as many laterally acquired genes that may be associated with a sympatric intracellular life (a community-associated lifestyle with viruses, bacteria, and eukaryotes) and the presence of virophages. By subculturing Mimivirus 150 times in a germ-free amoebal host, we observed the emergence of a bald form of the virus that lacked surface fibers...

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PMID: 21646533
DOI: 10.1073/pnas.1101118108

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