Article
Serologic type conversion of a herpes simplex virus type 1 (HSV-1) to an HSV-2 epitope caused by a single amino acid substitution in glycoprotein C.
Journal of virology - 1 Aug 1990
Kimmel K A, Dolter K E, Toth G M, Levine M, Glorioso J C
Abstract excerpt
A monoclonal antibody to herpes simplex virus type 2 glycoprotein C (gC-2) did not recognize wild-type herpes simplex virus type 1 gC (gC-1) but did recognize a mutant gC-1 molecule. This conversion from a type 1 to a type 2 epitope was shown to be due to a single amino acid substitution in gC-1.
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antigens, Surface
- L Cells
- Mice
- Molecular Sequence Data
- Mutation
- Sequence Homology, Nucleic Acid
- Serotyping
- Simplexvirus
- Viral Envelope Proteins