Article
Molecular diversity of the two sugar-binding sites of the β-trefoil lectin HA33/C (HA1) from Clostridium botulinum type C neurotoxin.
Archives of biochemistry and biophysics - 1 Aug 2011
Nakamura Toshio, Tonozuka Takashi, Ito Sakae, Takeda Yoichi, Sato Ryutaro, Matsuo Ichiro, Ito Yukishige, Oguma Keiji, Nishikawa Atsushi
Abstract excerpt
A critical role in internalizing the Clostridium botulinum neurotoxin into gastrointestinal cells is played by nontoxic components complexed with the toxin. One of the components, a β-trefoil lectin has been known as HA33 or HA1. The HA33 from C. botulinum type A (HA33/A) has been predicted to have a single sugar-binding site, while type C HA33 (HA33/C) has two sites. Here we constructed HA33/C mutants and...
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