Article
α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation.
BMC medicine - 3 Jun 2011
Shibata Masa-Aki, Iinuma Munekazu, Morimoto Junji, Kurose Hitomi, Akamatsu Kanako, Okuno Yasushi, Akao Yukihiro, Otsuki Yoshinori
Abstract excerpt
BACKGROUND: The mangosteen fruit has a long history of medicinal use in Chinese and Ayurvedic medicine. Recently, the compound α-mangostin, which is isolated from the pericarp of the fruit, was shown to induce cell death in various types of cancer cells in in vitro studies. This led us to investigate the antitumor growth and antimetastatic activities of α-mangostin in an immunocompetent xenograft model of mouse...
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