Article
Vaticanol C, a novel resveratrol tetramer, reduces lymph node and lung metastases of mouse mammary carcinoma carrying p53 mutation.
Cancer chemotherapy and pharmacology - 1 Oct 2007
Shibata Masa-Aki, Akao Yukihiro, Shibata Eiko, Nozawa Yoshinori, Ito Tetsuro, Mishima Satoshi, Morimoto Junji, Otsuki Yoshinori
Abstract excerpt
PURPOSE: The effects of vaticanol C (Vat-C), a novel resveratrol tetramer, were studied in a mouse metastatic mammary cancer model carrying mutations in p53 that produce a metastatic spectrum similar to that seen in human breast cancers. METHODS: Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879 cells, were subsequently treated with Vat-C at 0, 100 and 200 ppm in their diet. RESULTS:...
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