Article
Comparative morphological and biological studies on the itraconazole- and ketoconazole-resistant mutants of Cryptococcus neoformans.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology - 1 Jan 1990
Iwata K, Yamashita T, Ohsumi M, Baba M, Naito N, Taki A, Yamada N
Abstract excerpt
Studies were carried out on the resistance in vitro of Cryptococcus neoformans to the oral antifungal drugs itraconazole and ketoconazole. None of the six sensitive strains tested developed resistance to itraconazole or ketoconazole by serial transfer on Sabouraud's glucose agar plates containing increasing concentrations of either drug. One mutant resistant to itraconazole, and one mutant resistant to...
Topics
- Animals
- Antifungal Agents
- Cryptococcus
- Cryptococcus neoformans
- Culture Media
- Drug Resistance, Microbial
- Humans
- Itraconazole
- Ketoconazole
- Male