Article
Genetic variations in FOXO3A are associated with Bipolar Disorder without confering vulnerability for suicidal behavior.
Journal of affective disorders - 1 Oct 2011
Magno Luiz Alexandre V, Santana Cinthia V N, Sacramento Erika K, Rezende Vitor B, Cardoso Marcus V, Maurício-da-Silva Luiz, Neves Fernando S, Miranda Débora M, De Marco Luiz A, Correa Humberto, Romano-Silva Marco A
Abstract excerpt
BACKGROUND: Genetic variation plays an important role in Bipolar Disorder (BD) and suicide susceptibility. However, little is known about the genetic influence on the risk of suicide, particularly in BD patients. Since FOXO3A plays a role in distinct mood-relevant behavioral processes, this gene could be a novel gene candidate for BD. Thus, we investigated whether FOXO3A polymorphisms are associated with BD and...
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